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ORGAN TRANSPLANTS Procedure

Living Donor & Cadaveric Liver Transplantation

Orthotopic Liver Transplantation replaces a diseased, cirrhotic liver with a healthy right lobe graft from a living related donor or a whole cadaveric donor liver.

Liver transplant — living donor & cadaveric
Liver transplant — living donor & cadaveric

Clinical Overview & Disease Information

Orthotopic Liver Transplantation replaces a diseased, cirrhotic liver with a healthy right lobe graft from a living related donor or a whole cadaveric donor liver.

Signs & Symptoms

Early Symptoms
  • Persistent jaundice (yellowing of skin and eyes)
  • Dark amber urine and pale stools
  • Pruritus (intense skin itching)
Common Symptoms
  • Refractory ascites (fluid accumulation in abdomen)
  • Hepatic encephalopathy (confusion, memory loss)
  • Esophageal variceal bleeding
  • MELD Score > 15
Emergency Symptoms
  • Acute variceal hemorrhage with vomiting of blood
  • Grade 3/4 Hepatic Coma
  • Hepatorenal Syndrome

Causes & Risk Factors

Primary Causes & Etiology

  • Decompensated Hepatitis B / Hepatitis C Cirrhosis
  • Non-Alcoholic Steatohepatitis (NASH) / MASH
  • Alcoholic Liver Disease & Autoimmune Hepatitis
  • Hepatocellular Carcinoma (HCC) within Milan Criteria

Who is at Higher Risk?

  • Patients with MELD Score > 15
  • Decompensated cirrhosis with refractory ascites

Diagnostic Evaluation & Testing

Diagnostic Test Clinical Purpose / What It Shows
Triphasic Liver CT Angiogram & Volumetry Evaluates donor-recipient liver volume ratio (GRWR > 0.8%) and hepatic vascular anatomy
MRCP & Liver Biopsy Maps biliary tree anatomy and quantifies liver fibrosis stage

Comprehensive Treatment Options

Living Donor Right Lobe Liver Transplantation (LDLT)

Surgical harvest of 60-65% right liver lobe from a healthy related donor (HLA/blood group matched).

Key Advantages:
Planned elective procedure without waiting on cadaver list
Superior 1-year graft survival (> 92%)
Rapid liver regeneration in both donor and recipient within 8 weeks

Deceased Cadaveric Whole Liver Transplantation (DDLT)

Complete orthotopic liver replacement using a whole donor liver from a brain-dead cadaver donor.

Recommended For:
Patients without an eligible living donor
Acute Liver Failure (ALF) emergency status

Advanced Medical Technologies Available in Partner Hospitals

3D CT Hepatic Volumetry Intraoperative Doppler Flowmetry Cavallari Biliary Reconstruction Pigtail Catheter Drainage

Possible Complications If Untreated

Hepatic artery thrombosis
Biliary stricture or leak
Acute graft rejection
CMV infection

Recovery Timeline, Diet & Lifestyle Care

Recovery Timeline

Procedure / Stage Expected Recovery Duration
Liver Transplant ICU Stay 3 to 5 days
Step-Down Transplant Ward 10 to 14 days
Outpatient Immunosuppressant Leveling 3 to 6 months

Recommended Post-Treatment Diet

  • Strict clean cooked food diet (no raw salads/seafood)
  • High protein 1.5g/kg/day
  • Low sodium < 2g/day

Essential Lifestyle Changes

  • Take Tacrolimus at exact 12-hour intervals
  • Daily temperature, weight, and BP tracking
  • Wear N95 mask in public
When to Contact a Doctor Urgently:
Fever > 100.4°F (38°C)
Yellowing of eyes or dark urine
Right upper quadrant abdominal pain

Prevention & Long-Term Health

Hepatitis B vaccination
Lifelong Tacrolimus blood level (C0) monitoring

Frequently Asked Questions

How long does a living liver donor take to recover?

Living liver donors are discharged in 5-7 days and their liver regenerates to 90% full volume within 6 to 8 weeks.

Top Recommended Specialists Available

Dr. Rajesh Misra

Dr. Rajesh Misra

Chairperson - Anaesthesia

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Dr. Biswarup Purkayastha

Dr. Biswarup Purkayastha

Consultant – Heart & Lung Transplant and Vascular Surgery

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Dr. Kunal Vinayak

Dr. Kunal Vinayak

Associate Consultant - Urology & Kidney Transplant

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Dr. Rajesh Kumar Padhan

Dr. Rajesh Kumar Padhan

Chief – Academic and Training, Gastroenterology and Hepatology

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Dr. (Col) S. V. Kotwal

Dr. (Col) S. V. Kotwal

Chairperson Emeritus and DNB Teacher - Urology

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Dr. Varun Mittal

Dr. Varun Mittal

Head - Kidney Transplant & Associate Chief - Uro-Oncology & Robotic Surgery (Unit I)

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Dr. Rajiv Yadav

Dr. Rajiv Yadav

Chairperson Urology & Head, Urologic Oncology & Robotic Surgery (Unit I)

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Dr. Shweta Bansal

Dr. Shweta Bansal

Unit Head & Sr. Consultant - Respiratory Disease & Sleep Medicine (Unit II)

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Dr. Surendra Nath Khanna

Dr. Surendra Nath Khanna

Chairperson - Adult Cardiac Surgery & CTVS

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Dr. G. Arya Prakash

Dr. G. Arya Prakash

Head - Anesthesia for Liver Transplant & Critical Care

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Dr. Giriraj Bora

Dr. Giriraj Bora

Chairperson - Liver Transplant & Sr. Consultant - GI & HPB Surgery

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Dr. Lakshmi Kant Tripathi

Dr. Lakshmi Kant Tripathi

Chief - Nephrology (Unit II)

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Dr. Manju Aggarwal

Dr. Manju Aggarwal

Chief - Medical Services & Chairperson - Nephrology

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Dr. Mukesh Kumar Gupta

Dr. Mukesh Kumar Gupta

Head - Critical Care (Unit III) & Heart & Lung Transplant Team

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Dr. Narender Kumar

Dr. Narender Kumar

Head - Urology and Kidney Transplant Anesthesia

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Dr. Rajesh Misra

Dr. Rajesh Misra

Chairperson - Department of Anaesthesia & Perioperative Medicine

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Dr. Rati Bansal Goel

Dr. Rati Bansal Goel

Head - Critical Care (Unit III)

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Dr. Sakshi Karkra

Dr. Sakshi Karkra

Head - Pediatric Gastroenterology & Hepatology

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Dr. Shelly Mittal

Dr. Shelly Mittal

Chief - Anaesthesia & Regional Anaesthesia

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Dr. Shyam Sunder Mahansaria

Dr. Shyam Sunder Mahansaria

Head - Liver Transplant & Sr. Consultant - GI & HPB Surgery

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Dr. Swati Aggarwal

Dr. Swati Aggarwal

Principal Consultant - Anaesthesia

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Dr. Y Naveen

Dr. Y Naveen

Head - Anesthesia for Oncology & Transplant

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Dr. Mahendra Kumar

Dr. Mahendra Kumar

Consultant – Liver Transplant & HPB Surgery

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Dr. Dinesh Bansal

Dr. Dinesh Bansal

Chief - Nephrology & Interventional Nephrology (Unit III)

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Global Cost Comparison Matrix

Procedure USA (Avg) India (ISG) Turkey (Avg) Thailand (Avg)
Liver transplant — living donor & cadaveric $180,000 $26,000 $45,000 $50,000

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Commonly Prescribed Medications

  • Tacrolimus (Prograf) 1mg twice daily
  • Mycophenolate Mofetil 500mg twice daily
  • Prednisolone 5mg
  • Valganciclovir 450mg

International Patient Guide

Estimated Stay in India:
Donor-Recipient Evaluation & State Committee Clearance 5 - 7 days
Transplant Surgery & Hospital Stay 14 - 21 days
Outpatient Clearance & Return Flight 30 - 45 days total stay
Documents to Bring:
  • Passport & Medical Visa
  • State Transplant Authorization Committee Approval
  • Triphasic Liver CT & Blood Group Records